abstract：:Chronic liver disease is generally widespread, and a test for screening fibrotic subjects in a large population is needed. The ability of Wisteria floribunda agglutinin-positive mac-2 binding protein (WFA+-M2BP) to detect significant fibrosis was investigated in health checkup subjects in this research. Of 2021 health...

journal_title：International journal of molecular sciences

authors： Tamaki N,Kurosaki M,Takahashi Y,Itakura Y,Kirino S,Inada K,Yamashita K,Sekiguchi S,Hayakawa Y,Osawa L,Higuchi M,Takaura K,Maeyashiki C,Kaneko S,Yasui Y,Tsuchiya K,Nakanishi H,Itakura J,Loomba R,Izumi N

更新日期：2020-12-22 00:00:00

abstract：:Microbiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The bidirectional relationship between the...

journal_title：International journal of molecular sciences

authors： Micó-Carnero M,Rojano-Alfonso C,Álvarez-Mercado AI,Gracia-Sancho J,Casillas-Ramírez A,Peralta C

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...

journal_title：International journal of molecular sciences

authors： Lorusso F,Inchingolo F,Dipalma G,Postiglione F,Fulle S,Scarano A

更新日期：2020-12-21 00:00:00

abstract：:G protein-coupled receptors are linked to various intracellular transducers, each pathway associated with different physiological effects. Biased ligands, capable of activating one pathway over another, are gaining attention for their therapeutic potential, as they could selectively activate beneficial pathways whilst...

journal_title：International journal of molecular sciences

authors： Denzinger K,Nguyen TN,Noonan T,Wolber G,Bermudez M

更新日期：2020-12-20 00:00:00

abstract：:Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and h...

journal_title：International journal of molecular sciences

authors： Sawada Y,Mashima E,Saito-Sasaki N,Nakamura M

更新日期：2020-12-20 00:00:00

abstract：:Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....

journal_title：International journal of molecular sciences

authors： Holmes A,Rossez Y,Wright KM,Hedley PE,Morris J,Willats WGT,Holden NJ

更新日期：2020-12-19 00:00:00

abstract：:Obesity is a risk factor for Alzheimer's disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid β (Aβ) in overweight mice because its systemic elimination may impact brain Aβ load, a major landmark of AD pathology. We also analyzed whether circulating insulin-like growth fac...

journal_title：International journal of molecular sciences

authors： Herrero-Labrador R,Trueba-Saiz A,Martinez-Rachadell L,Fernandez de Sevilla ME,Zegarra-Valdivia JA,Pignatelli J,Diaz-Pacheco S,Fernandez AM,Torres Aleman I

更新日期：2020-12-18 00:00:00

abstract：:Recently, extreme ultraviolet (EUV) radiation has been increasingly used to modify polymers. Properties such as the extremely short absorption lengths in polymers and the very strong interaction of EUV photons with materials may play a key role in achieving new biomaterials. The purpose of the study was to examine the...

journal_title：International journal of molecular sciences

authors： Lech A,Butruk-Raszeja BA,Ciach T,Lawniczak-Jablonska K,Kuzmiuk P,Bartnik A,Wachulak P,Fiedorowicz H

更新日期：2020-12-18 00:00:00

abstract：:Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dep...

journal_title：International journal of molecular sciences

authors： Kalezic A,Udicki M,Srdic Galic B,Aleksic M,Korac A,Jankovic A,Korac B

更新日期：2020-12-18 00:00:00

abstract：:Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not ...

journal_title：International journal of molecular sciences

authors： Minamoto T,Nakayama K,Ishibashi T,Ishikawa M,Nakamura K,Yamashita H,Shanta K,Mahmud HM,Razia S,Iida K,Sakashita G,Nakamura T,Kanda H,Kyo S

更新日期：2020-12-18 00:00:00

abstract：:Psychedelic and stimulating phenethylamines belong to the family of new psychoactive substances (NPS). The acute toxicity framework has begun to be investigated, while studies showing genotoxic potential are very limited or not available. Therefore, in order to fill this gap, the aim of the present work was to evaluat...

journal_title：International journal of molecular sciences

authors： Cocchi V,Gasperini S,Hrelia P,Tirri M,Marti M,Lenzi M

更新日期：2020-12-17 00:00:00

abstract：:Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich's ataxia. Frataxin's actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the biosynthetic iron-su...

journal_title：International journal of molecular sciences

authors： Doni D,Passerini L,Audran G,Marque SRA,Schulz M,Santos J,Costantini P,Bortolus M,Carbonera D

更新日期：2020-12-17 00:00:00

abstract：:Paired box gene 3 (Pax3) and cAMP responsive element-binding protein (CREB) directly interact with the cis-acting elements on the promoter of microphthalmia-associated transcription factor isoform M (MITF-M) for transcriptional activation in the melanogenic process. Tyrosinase (Tyro) is a target gene of MITF-M, and fu...

journal_title：International journal of molecular sciences

authors： Choi YP,Kim GH,Kim SH,Maeng J,Lee H,Han SB,Kim KH,Kim Y

更新日期：2020-12-17 00:00:00

abstract：:Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical neur...

journal_title：International journal of molecular sciences

authors： Tempio A,Niso M,Laera L,Trisolini L,Favia M,Ciranna L,Marzulli D,Petrosillo G,Pierri CL,Lacivita E,Leopoldo M

更新日期：2020-12-17 00:00:00

abstract：:Cell-cell fusion between eukaryotic cells is a general process involved in many physiological and pathological conditions, including infections by bacteria, parasites, and viruses. As obligate intracellular pathogens, viruses use intracellular machineries and pathways for efficient replication in their host target cel...

journal_title：International journal of molecular sciences

authors： Leroy H,Han M,Woottum M,Bracq L,Bouchet J,Xie M,Benichou S

更新日期：2020-12-17 00:00:00

abstract：:Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show similar metabolomic patterns several years postpartum. Targeted metabol...

journal_title：International journal of molecular sciences

authors： Ott R,Pawlow X,Weiß A,Hofelich A,Herbst M,Hummel N,Prehn C,Adamski J,Römisch-Margl W,Kastenmüller G,Ziegler AG,Hummel S

更新日期：2020-12-17 00:00:00

abstract：:The strong association with the Major Histocompatibility Complex (MHC) class I genes represents a shared trait for a group of autoimmune/autoinflammatory disorders having in common immunopathogenetic basis as well as clinical features. Accordingly, the main risk factors for Ankylosing Spondylitis (AS), prototype of th...

journal_title：International journal of molecular sciences

authors： Tedeschi V,Paldino G,Paladini F,Mattorre B,Tuosto L,Sorrentino R,Fiorillo MT

更新日期：2020-12-17 00:00:00

abstract：:Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcr...

journal_title：International journal of molecular sciences

authors： Moreno-García L,López-Royo T,Calvo AC,Toivonen JM,de la Torre M,Moreno-Martínez L,Molina N,Aparicio P,Zaragoza P,Manzano R,Osta R

更新日期：2020-12-16 00:00:00

abstract：:Congenital cataracts are the prime cause for irreversible blindness in children. The global incidence of congenital cataract is 2.2-13.6 per 10,000 births, with the highest prevalence in Asia. Nearly half of the congenital cataracts are of familial nature, with a predominant autosomal dominant pattern of inheritance. ...

journal_title：International journal of molecular sciences

authors： Kandaswamy DK,Prakash MVS,Graw J,Koller S,Magyar I,Tiwari A,Berger W,Santhiya ST

更新日期：2020-12-16 00:00:00

abstract：:Soil salinity is a key problem for crop production worldwide. High salt concentration in soil negatively modulates plant growth and development. In roots, salinity affects the growth and development of both primary and lateral roots. The phytohormone auxin regulates various developmental processes during the plant's l...

journal_title：International journal of molecular sciences

authors： Garrido-Vargas F,Godoy T,Tejos R,O'Brien JA

更新日期：2020-12-15 00:00:00

abstract：:Thyroid cancer incidence has increased worldwide; however, investigations of thyroid cancer-related factors as potential prognosis markers remain insufficient. Secreted proteins from the cancer secretome are regulators of several molecular mechanisms and are, thereby, ideal candidates for potential markers. We aimed t...

journal_title：International journal of molecular sciences

authors： Kim EK,Song MJ,Jang HH,Chung YS

更新日期：2020-12-15 00:00:00

abstract：:Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165...

journal_title：International journal of molecular sciences

authors： Zampino M,Tanaka T,Ubaida-Mohien C,Fantoni G,Candia J,Semba RD,Ferrucci L

更新日期：2020-12-15 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen frequently associated with acute diarrhea in children and travelers to endemic regions. EAEC was found the most prevalent bacterial diarrheal pathogen from hospitalized Bolivian children less than five years of age with acute diarrhea from 2007 to 2010....

journal_title：International journal of molecular sciences

authors： Joffré E,Iñiguez Rojas V

更新日期：2020-12-15 00:00:00

abstract：:A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system. Catecholamines themselves are synthesized by the L-dopa decarboxylase (DDC). The aim of our study...

journal_title：International journal of molecular sciences

authors： Tremmel E,Kuhn C,Kaltofen T,Vilsmaier T,Mayr D,Mahner S,Ditsch N,Jeschke U,Vattai A

更新日期：2020-12-15 00:00:00

abstract：:Laser-driven accelerators allow to generate ultrashort (from femto- to picoseconds) high peak dose-rate (up to tens of GGy/s) accelerated particle beams. However, the radiobiological effects of ultrashort pulsed irradiation are still poorly studied. The aim of this work was to compare the formation and elimination of ...

journal_title：International journal of molecular sciences

authors： Babayan N,Vorobyeva N,Grigoryan B,Grekhova A,Pustovalova M,Rodneva S,Fedotov Y,Tsakanova G,Aroutiounian R,Osipov A

更新日期：2020-12-14 00:00:00

abstract：:Hypoxia, a common factor ruling the microenvironment composition, leads to tumor progression. In this hypoxic context, cytokines and cells cooperate to favor cancer development and metastasis. Tumor hypoxia is heterogeneously distributed. Oxygen gradients depend on the vicinity, functionality of blood vessels, and oxy...

journal_title：International journal of molecular sciences

authors： Klemba A,Bodnar L,Was H,Brodaczewska KK,Wcislo G,Szczylik CA,Kieda C

更新日期：2020-12-14 00:00:00

abstract：INTRODUCTION:Studies have shown that long-term positive behavioural and physiological changes are induced in connection with vaginal, physiological birth, and skin-to-skin contact after birth in mothers and babies. Some of these effects are consistent with the effect profile of oxytocin. This scoping review explores wh...

journal_title：International journal of molecular sciences

authors： Uvnäs-Moberg K,Gross MM,Agius A,Downe S,Calleja-Agius J

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:The determinants that mediate the interactions between microRNAs and the gut microbiome impacting on obesity are scarcely understood. Thus, the aim of this study was to investigate possible interactions between circulating microRNAs and gut microbiota composition in obesity. METHOD:The sample comprised 78 s...

journal_title：International journal of molecular sciences

authors： Assmann TS,Cuevas-Sierra A,Riezu-Boj JI,Milagro FI,Martínez JA

更新日期：2020-12-14 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes including organ development and homeostasis, epigenomic and transcriptomic regulation, gene repression and imprinting, and DNA damage repair. A widely known function of EZH2 is to serve as an enzymatic subunit of Polycomb repres...

journal_title：International journal of molecular sciences

authors： Wang J,Wang GG

更新日期：2020-12-14 00:00:00

abstract：:Self-assembled peptide nanofibers (NFs) obtained from β-sheet peptides conjugated with drugs, including antigenic peptides, have recently attracted significant attention. However, extensive studies on the interactions of β-sheet peptide NFs with model cell membranes have not been reported. In this study, we investigat...

journal_title：International journal of molecular sciences

authors： Waku T,Kasai A,Kobori A,Tanaka N

更新日期：2020-12-14 00:00:00

abstract：:For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One of the Nups, Elys, i...

journal_title：International journal of molecular sciences

authors： Shevelyov YY

更新日期：2020-12-13 00:00:00

abstract：:Streptococcus mutans (S. mutans) is widely regarded as the main cause of human dental caries via three main virulence factors: adhesion, acidogenicity, and aciduricity. Citric acid is one of the antibiotic agents that can inhibit the virulence capabilities of S. mutans. A full understanding of the acidic resistance me...

journal_title：International journal of molecular sciences

authors： Nguyen LTP,Liu BH

更新日期：2020-12-13 00:00:00

abstract：:Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of suc...

journal_title：International journal of molecular sciences

authors： Lara-Espinosa JV,Santana-Martínez RA,Maldonado PD,Zetter M,Becerril-Villanueva E,Pérez-Sánchez G,Pavón L,Mata-Espinosa D,Barrios-Payán J,López-Torres MO,Marquina-Castillo B,Hernández-Pando R

更新日期：2020-12-13 00:00:00

abstract：:In the present study, we aim to identify the effect of restrain stress (RS) on the expression of miRNAs in mouse serum. We used three genotypes of animals (mice with knock-out of the gene-encoding norepinephrine transporter, NET-KO; C57BL/6J, and SWR/J) which had previously been shown to display different sensitivity ...

journal_title：International journal of molecular sciences

authors： Solich J,Kuśmider M,Faron-Górecka A,Pabian P,Dziedzicka-Wasylewska M

更新日期：2020-12-12 00:00:00

abstract：:Autophagy (cellular self-consumption) is a crucial adaptation mechanism during cellular stress conditions. This study aimed to examine how this important process is regulated in human periodontal ligament (PDL) fibroblasts by mechanical and inflammatory stress conditions and whether the mammalian target of rapamycin (...

journal_title：International journal of molecular sciences

authors： Blawat K,Mayr A,Hardt M,Kirschneck C,Nokhbehsaim M,Behl C,Deschner J,Jäger A,Memmert S

更新日期：2020-12-11 00:00:00

abstract：:Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endome...

journal_title：International journal of molecular sciences

authors： García-Ibañez P,Yepes-Molina L,Ruiz-Alcaraz AJ,Martínez-Esparza M,Moreno DA,Carvajal M,García-Peñarrubia P

更新日期：2020-12-10 00:00:00

abstract：:As part of the optimization of assisted reproductive technology programs, the aim of the study was to identify key small noncoding RNA (sncRNA) molecules that participate in maternal-to-zygotic transition and determine development potential and competence to form a healthy fetus. Small RNA deep sequencing followed by ...

journal_title：International journal of molecular sciences

authors： Timofeeva A,Drapkina Y,Fedorov I,Chagovets V,Makarova N,Shamina M,Kalinina E,Sukhikh G

更新日期：2020-12-10 00:00:00

abstract：:Gastric cancer (GC) is a deadly disease with poor prognosis that is characterized by heterogeneity. New classifications based on histologic features, genotypes, and molecular phenotypes, for example, the Cancer Genome Atlas subtypes and those by the Asian Cancer Research Group, help understand the carcinogenic differe...

journal_title：International journal of molecular sciences

authors： Re V,Brisotto G,Repetto O,De Zorzi M,Caggiari L,Zanussi S,Alessandrini L,Canzonieri V,Miolo G,Puglisi F,Belluco C,Steffan A,Cannizzaro R

更新日期：2020-12-10 00:00:00

abstract：:The chloromethyl-functionalized polystyrene is the most commonly used ammonium cation precursor for making anion exchange resins (AER) and membranes (AEM). However, the chloromethylation of polystyrene or styrene involves highly toxic and carcinogenic raw materials (e.g., chloromethyl ether) and the resultant ammonium...

journal_title：International journal of molecular sciences

authors： Gui Q,Ouyang Q,Xu C,Ding H,Shi S,Chen X

更新日期：2020-12-10 00:00:00

abstract：:Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins which are usually involved in the development and progression of cancer. Carbonic anhydrase XII (CA XII) contributes to the survival of tumors under hypoxic conditi...

journal_title：International journal of molecular sciences

authors： Stravinskiene D,Sliziene A,Baranauskiene L,Petrikaite V,Zvirbliene A

更新日期：2020-12-10 00:00:00